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Im probably not the best person to answer this, but not only am I the spokesperson, but Im also one of the members

Current research suggests that metabolic rate reductions during GLP-1 treatment are primarily attributable to weight loss itself rather than a direct medication effect

Newer incretin-based therapies and considerations for pregnancy Emerging therapies that target multiple incretin pathways such as Retatrutide (a triple agonist targeting GLP-1, GIP and glucagon receptors) and Cagrisema (a dual agonist mimicking GLP-1 and amylin) will require thorough investigation for their safety and efficacy in pregnancy

Thyroid tumors: Animal studies showed increased thyroid tumors

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But the reality is that Januvia isnt that effective for weight loss