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When released in response to dietary fat in the small intestine, CCK binds to CCK1 receptors on vagal afferent neurons, initiating a cascade that activates these neurons and transmits signals to the NTS in the brainstem
It was noted that heart failure remained a complication with limited risk-based prevention in clinical practice [79]
Retatrutide is the first medication in this class that hits 3 different biological targets
