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Eighty male SD rats were randomly divided into eight groups (n=10): blank control (CON), high-fat diet control (HFD), uric acid nephropathy (UN), Mazdutide low/medium/high-dose groups (0.025/0.05/0.075 mgkg), semaglutide group (GLP-1RA, mgkg), and allopurinol group (ALL, 25 mgkg)