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and patents pending from Roche Diabetes Care

Considering this, the reported side effects may be GLP-1 receptor activation-related, but the exact mechanism is still unknown

4 , 5 Given their expanding use in populations with obesity, T2DM, and cardiovascular disease, a deeper understanding of their impact on BP is increasingly relevant

That experimental therapy combines GLP-1 and GIP with activation of nuclear hormone receptors known as PPARs targets once used by diabetes drugs like rosiglitazone and pioglitazone

Odds of gastrointestinal events were similar between tirzepatide and GLP-1 RAs, except for diarrhoea with tirzepatide 10 mg (OR 1.51 [95% CI 1.07, 2.15], I 2 0%) (Table 2)

Switching between GLP-1 medications does happen in clinical practice, usually when a patient has reached a plateau, experienced intolerable side effects, or when insurance coverage changes