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The FDA has raised concerns about unapproved GLP-1 drugs used for weight loss, including fraudulent compounded products, dosing errors, and adverse event reports involving compounded semaglutide and tirzepatide.

GLP-1 medications like Semaglutide and Tirzepatide have been shown to increase Testosterone levels in men with obesity by 53% to 77% over 18 months

Behaviour Research and Therapy, 41(5), 509-528

Additionally, when GLP1R knockout mice were used to validate the impact of exenatide and liraglutide, no increase in calcitonin secretion or C-cell hyperplasia was observed

Mansur RB, Ahmed J, Cha DS, Woldeyohannes HO, Subramaniapillai M, Lovshin J, et al

Gallbladder problems have happened in some people who take RYBELSUS