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Novel and Investigational Therapies Newer agents are under investigation that target diverse gastric (fundic, antral, and pyloric) motor functions, including novel serotonergic 5-HT4 agonists, dopaminergic D2/3 antagonists, neurokinin NK-1 antagonists, and motilin and ghrelin agonists

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Physiological Basis Of Exercise Tolerance Causes Of Reduced Exercise Tolerance Exercise Testing and Clinical Assessment Improving Exercise Tolerance Clinical Significance References Further Reading Exercise tolerance captures how efficiently the body delivers and utilizes oxygen during physical activity, making it a powerful indicator of functional capacity, disease burden, and response to rehabilitation