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The underlying reason is that, in the case of parenteral presentations, the effective doses of GLT-1 receptor agonists necessary for weight control are greater than those needed for glycemic control

Semaglutide : Selective GLP-1 receptor agonist that suppresses appetite, delays gastric emptying, and enhances glucose-dependent insulin secretion

But dont be surprised if your provider recommends switching later on

Intestinal release of GLP-1 augments initial insulin secretion in vivo in part through a vagal-vagal reflex leading to cholinergic stimulation of islet beta cells

This unique mechanism of action, dubbed the triple G approach, sets retatrutide apart from traditional obesity medications such as semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro), that typically target only one or two of these key metabolic regulators