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It showed suggestive associations with a reduced risk of Tourettes syndrome but a higher risk of anorexia nervosa
Summary: No natural supplement has been shown to replicate the clinical benefits of prescribed GLP-1 or GIP receptor agonists for diabetes management or weight loss
The phase 2 T2D trial similarly reported a safe and well-tolerated profile
Setmelanotide is FDA approved for ages 6 years and older to treat monogenic obesity due to variants that are pathogenic, likely pathogenic or variant of unknown significance (VUS) in POMC (pro opiomelanocortin), PCSK1 (proprotein convertase subtilisin/kexin type 1), LEPR (leptin receptor) and Bardet Biedl Syndrome (BBS)
Their repurposing aligns with precision medicine paradigms, enabling tailored therapies for patients with comorbid conditions like obesity, diabetes, and chronic pain
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