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Importantly, these associations persist after accounting for improvements in glycemic control and body weight, suggesting that the observed neuroprotective signal may not be solely attributable to better metabolic management

Still, all changes were interpreted as minor and non-clinically significant [23, 24, 30, 32, 38]

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Short surveys with obesity-clinic dietitians validated price sensitivity and substitution assumptions drawn from secondary data

Motor disturbances/hypoactivity Another concern with therapies targeting the mesolimbic system is that the behavioral outcomes obtained are not specific to ingestive behavior and mediated via a general increase or decrease in physical activity

When compared to the control group, TG contents in pancreatic tissue of rats in T2DM and T2DM + sham groups significantly increased, while it observably decreased after surgery in T2DM + RYGB and T2DM + EX-4 groups (Figure 6K)