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Thomas MK, Nikooienejad A, Bray R, Cui X, Wilson J, Duffin K, Milicevic Z, Haupt A, Robins DA (2021) Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes

Body composition research One of the most important questions in obesity pharmacotherapy is whether weight loss preserves or degrades lean body mass

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188,208 Although a modest reduction in lean mass was observed at 12 months, muscle function, assessed via handgrip strength, improved significantly, the prevalence of sarcopenic obesity declined, and resting energy expenditure relative to lean mass increasedindicating enhanced metabolic efficiency
The TRIUMPH-4 data confirm that retatrutide achieves greater peak weight loss, but CagriSema's nearer-term availability and established semaglutide safety record may make it the first to reach patients

Its once-weekly subcutaneous injection regimen improves patient adherence by simplifying the treatment routine, making it an attractive option for both patients and healthcare providers