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JAMA Neurol 79(9):846855

Published phase 2 research reported that the most common adverse events in retatrutide groups were gastrointestinal, dose-related, and mostly mild to moderate in severity

Published research shows 19.1% average weight loss at 12 months

1 So the honest version of the question is not how does it work in PCOS? but is there a defensible reason to think it would improve insulin resistance in PCOS, and how far can we reason from the data that actually exist? That reframing is not evasion

If fatigue persists or worsens, its crucial to discuss it with your healthcare provider to explore potential causes and solutions

however, rare complications can extend symptoms even longer