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Masculinized mutants lack male somatic tissues, but they produce a large number of sperm 26 , substantially greater than the ~300 sperm typically produced by hermaphrodites

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Schandelmaier S, Briel M, Varadhan R et al (2020) Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses

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Myokines produced by skeletal muscle, such as interleukin-6 (IL-6) and irisin, play a key role in mediating these immune and metabolic responses through autocrine, paracrine, and endocrine effects