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16 Tirzepatide Ile 27 is akin to GLP-1 Val 27 and GIP Leu 27

These gut-derived hormones are released in response to food intake, and have the following effects: Promoting insulin release (insulin lowers blood sugar) Blocking glucagon release (glucagon raises blood sugar) Delaying gastric emptying to prevent post-meal highs Promoting a feeling of fullness so you eat less at any given meal Previously approved incretin-based therapies mimic only the GLP-1 hormone

[DOI] [PubMed] [Google Scholar] 32.Giacco F., Brownlee M

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Their effects depend on the metabolic environment they enter

For instance, chronic constipation may lead to haemorrhoids or anal fissures, whilst severe diarrhoea could cause irritation of the rectal mucosa