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PMID: Summary Keywords biologic therapy, early psoriatic arthritis, GLP-1 receptor agonists, inflammation, metabolic syndrome, psoriasis Citation Ciancio G, Maranini B, Sandri G, Amati G, Bortoluzzi A, Silvagni E, Govoni M and Giuggioli D (2026) Glucagon-like peptide-1 receptor agonists in psoriasis and psoriatic arthritis: emerging evidence and future research opportunities

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The landmark LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) trial, which enrolled 9340 individuals with T2D at high CV risk, demonstrated that liraglutide significantly reduced the incidence of major adverse cardiovascular events (MACE) compared with placebo over a median follow-up of 3.8 years (Hazard Ratio [HR]: 0.87

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So while the medications can produce remission-like states, theyre managing the condition rather than permanently curing it

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