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Rapid weight loss can also affect collagen production, contributing to sagging skin and an older appearance

Both drugs can have side effects, and using them together may increase the chances of certain adverse reactions

Retatrutide is an investigational triple agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, enhancing insulin secretion, suppressing appetite, increasing energy expenditure, and promoting hepatic fat oxidation

Some people may notice positive changes in their appetite, such as reduced cravings or feeling more satisfied between meals, within a few weeks, but the most significant results are likely to happen when you reach the maintenance dose from around week 13 of treatment

All recordings were captured at 2025C

SUSTAIN-6 documented significant reduction in major adverse cardiovascular events in type 2 diabetes patients with established cardiovascular disease, and SELECT documented cardiovascular event reduction in obese patients without diabetes