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10.1073/pnas.1411131111 Proc

December 2025 brought FDA approval for the oral version, designed for adults with obesity or overweight who also have at least one connected health issue

In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 2007 and Campbell and Drucker, 1992

The study, involving 17,000 people, found that the drug reduced the overall chance someone would die for any reason (known as all-cause mortality) by 19%

a smaller group holds at 2.5 mg or below Sub-2.5 mg maintenance is unstudied

Its best-known function is raising blood glucose the counterpart to insulin