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Description
Formulations of GLP-1 with extended duration The enzyme DPP-4 is responsible for the rapid inactivation of GLP-1, although some GLP-1 is also removed from the circulation by renal clearance and by the enzyme neutral endopeptidase [11]
In healthy and type-2 diabetic humans, it has been consistently demonstrated, that GIP, even in rather high (supraphysiological) doses, does not lead to GLP-1 secretion [[328], [329], [330]]
doi: 10.1677/jme.0.0100259 44 GallwitzBWittMPaetzoldGMorys-WortmannCZimmermannBEckartKet al
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