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Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig

In a meta-analysis of 38 randomized controlled trials (2199 children and adolescents, mean age 13.7 years

Pfeifer, K

21 November 2014

in humans, an association between sDPP-4 and triglyceride levels was evidenced, while patients treated for 24 months with a DPP-4is-based combination with metformin exhibited an improved lipid profile, especially for triglycerides and LDL, when compared to baseline in T2D patients [67]

Smitha et al., 2014)