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22 (2005): 79647969, 10.1073/pnas.0405277102

A small percentage of large employers contract directly with providers, such as hospitals or health systems, to provide for their employees outside of their health plans network

Everyone in oncology is grappling with how to assess clinical relevance, says Hartmann, and there will be increasing pressure to introduce new drugs earlier in treatment lines for ethical reasons, but this will make overall survival harder to assess for a certain agent and puts more emphasis on wider quality-of-life benefits and surrogate measures of possible success

It also slows down digestion through delayed gastric emptying, which helps stabilize blood sugar regulation and prevents sharp spikes after meals

The clinical implication: aggressive dose escalation in lower-BMI users is the tolerability problem, not the compound itself

Mix cardio (3-4x/week) and strength (2-3x/week) for balance