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While the body does produce natural GLP-1, this endogenous hormone is rapidly broken down by the enzyme dipeptidyl peptidase-4 (DPP-4) within minutes of secretion, making it unsuitable as a therapeutic agent without pharmaceutical modification

Ozempic, for example, is a lower dose of Wegovy and still prescribed for Type-2 diabetes

This means companies that continue to offer compounded tirzepatide may be operating in legally questionable territory unless they can demonstrate legitimate patient-specific medical necessity for each prescription
[DOI] [PubMed] [Google Scholar] 235.Chacn F., Esquifino A.I., Perell M., Cardinali D.P., Spinedi E., Alvarez M.P

Those companies, insurers say, have charged exorbitant amounts for the weight loss medicines, and the costs to insurers were unsustainable

However, studies have shown that retinal layer thickness is significantly lower in pwIIH compared to healthy controls, meaning that axonal loss is more widespread than previously suspected, and also occurs in apparently effectively treated pwIIH and/or patients not reporting any visual disturbances at all [35]
