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The opioid epidemic is now dominated by illicitly manufactured fentanyl and death tolls continue to mount

Gault et al

Highlights of 2024: The year the obesity market took shape The market for anti-obesity medications (AOMs) reached a major milestone in 2024 with global spend exceeding $30Bn for the first time, an over ten-fold increase since 2020

Electrophysiological whole-cell voltage- and current-clamp recordings in horizontal or coronal brainstem slices has revealed a rapid leptin-induced depolarization of these NTS GCG + neurons, thus confirming the ability of leptin to directly stimulate central GLP-1 secretion [351]

doi: 10.1056/NEJMoa2032183 [DOI] [PubMed] [Google Scholar] 41.Gleason PP, Urick BY, Marshall LZ, Friedlander N, Qiu Y, Leslie RS

Additionally, up to 90% of participants on eloralintide improved by at least one BMI category, she added