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"So I really want to encourage healthiness, and not about the number on a scale

Titration Complexities Slow titration, while necessary to reduce side effects, delays the onset of maximum efficacy

The FDA released a safety announcement in 2015 which alerted providers to report severe and persistent joint pain with use of DPP-4 inhibitors

Regul Pept 51:6374

Side effects that have been reported with Ozempic can include: nausea and vomiting flatulence constipation diarrhea abdominal pain fatigue injection site reactions In rare instances, you may also experience serious side effects such as: vision changes kidney problems gall bladder disease severe allergic reactions an increased risk of thyroid cancer hypoglycemia (low blood sugar) pancreatitis (inflammation of the pancreas) In some cases, you may be unable to prevent facial side effects from Ozempic

Constipation is a documented side effect of semaglutide and tirzepatide, with the FDA prescribing information listing it as a common adverse event in the clinical trial populations