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Peripheral IR primarily involves reduced insulin-mediated glucose uptake by skeletal muscle and adipose tissue, driven by defects in the insulin receptor substrate and downstream signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), leading to diminished translocation of glucose transporter type 4 (SLC2A4/GLUT4) and glucose uptake [5]

Within this multifaceted pathological landscape, the GLP-1 system has emerged as a cornerstone of modern metabolic pharmacology, transcending its initial role as a simple glycemia-regulating incretin (Kong et al., 2026

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Both medications require gradual titration over 3-5 months before reaching maintenance doses

While such medications are typically recommended for morbidly obese individuals, in India, film stars and affluent individuals are already using them