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Surrogating and redirection of pyrazolo [1, 5-a] pyrimidin-7 (4H)-one core, a novel class of potent and selective DPP-4 inhibitors

(2026): Glucagon-like peptide 1-based therapies for the treatment of type 2 diabetes mellitus

Lancet 2018;392:2180-93.ArticlePubMed 127

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Another significant advancement is MariTide, developed by Amgen