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Once-Weekly Semaglutide 72 mg in Adults with Obesity (STEP UP)

BMI thresholds still exist because clinical trials primarily studied patients meeting specific BMI requirements, and FDA indications and insurance policies are generally based on those populations

doi: 10.1016/j.ejps.2012.07.003

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Coutinho W, Halpern B

Weight loss continues at the lower dose, albeit at a slower rate, and the metabolic health improvements accumulated during the higher-dose phase persist as long as the protocol continues