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By Nancy Lapid June 8 (Reuters) - Use of GLP-1 drugs for diabetes or obesity early in the first trimester of pregnancy, before a woman realizes she is pregnant, is not a cause for alarm, a large new data analysis suggests

In 2023, the American Academy of Pediatrics (AAP) released clinical guidelines for the evaluation and treatment of children and adolescents with obesity, recommending the more prompt use of treatments previously considered intensive and thus restricted

Substrate Utilization and Endurance Performance Exercise performance depends heavily on substrate availability

The key is achieving sustainable results through comprehensive medical supportnot yo-yo dieting that can worsen metabolic health over time

The role of GLP-1 receptor agonists here is already well established, and many people describe a reduction not just in appetite but in compulsive preoccupation with eating what some have called the quieting of food noise. That matters because it suggests these medications may alter not only consumption but the subjective urgency of craving itself

In clinical studies treatment with liraglutide was associated with an increase in HR (mean difference 7 bpm) and more serious cardiac adverse events (3% vs 10% for placebo and liraglutide, respectively) in chronic heart failure patients with and without type 2 diabetes (135)