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Diabetic ketoacidosis as an effect of sodium-glucose cotransporter 2 inhibitor: real world insights

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However, abdominal symptoms are often related to acute pancreatis, but extensive cardiovascular outcome trials have not demonstrated an elevated risk of pancreatitis associated with GLP-1RAs [60]

Abbreviations AEs: Adverse events NAEs: Neurological adverse events FDA: The Food and Drug Administration FAERS: The FDA Adverse Event Reporting System GLP-1 RAs: Glucagon-like peptide-1 receptor agonists ADRs: Adverse drug reactions PTs: Preferred Terms SOCs: System Organ Classes IQR: Interquartile range ROR: Reporting odds ratio CI: Confidence interval PRR: Proportional reporting ratio BCPNN: Bayesian Confidence Propagation Neural Network EBGM: Empirical Bayesian geometric mean EBGM05: The lower limit of 95% CI of EBGM IC: Information component IC025: The lower limit of 95% CI of the IC VANs: Vagal afferent neurons T2DM: Type 2 diabetes mellitus OR: Odds ratios References Targher, G., Mantovani, A

Collectively, these findings suggest that tirzepatide may affect OSAS severity predominantly through metabolic and inflammatory improvement, with potential adjunctive neuromuscular contributions

Bo Bai, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers