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Nauck MA, Meier JJ, Cavender MA, et al

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Evidence was critically appraised following the CASP checklist

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With time, the success stories eased concerns

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Such an absence is not surprising given that this is still a relatively new aesthetic populationbut inevitably means that much of the guidance is derived from expert opinion rather than from study outcomes

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You lose visual contact with the injection site, which increases the risk of hitting muscle tissue instead of the subcutaneous layer

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Acta Pharmaceutica Sinica

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