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Ozempic may contribute to an increased risk for thyroid c-cell tumors, acute pancreatitis, gallbladder disease, hypoglyceia, acute kidney injury, severe GI side effects, and an increased risk for worsening of diabetic retinopathy in people with type 2 diabetes

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GPCRs that are agonist-activated promote the synthesis of guanine triphosphate (GTP), which when bound to the G-protein causes the Ga and Gbc subunits to separate, which in turn can activate signaling proteins downstream [52]

Estos efectos pleiotrpicos explican por qu la GLP-1 se ha convertido en un objetivo teraputico importante para el tratamiento de la diabetes tipo 2 y, ms recientemente, para el manejo del sobrepeso y la obesidad