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Preclinical studies have demonstrated that GLP-1 receptor agonists have neuroprotective effects, including reducing neuroinflammation, promoting neurogenesis, and improving synaptic plasticity

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Pulse & Remedy claims peptide therapy "is considered safe for extended use" without citing a study behind that statement, underscoring the regulatory gap between non-prescription peptides and FDA-approved GLP-1 drugs

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Ahn and co-workers, for instance, have prepared a series of conformationally constrained GLP-1 analogs by introducing multiple lactam bridges between Glu i and Lys i +4 to stabilize two -helices at the N- and C-terminal regions