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An extension analysis of patients from Novo Nordisks own STEP1 trial found that one year after withdrawal of onceweekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained twothirds of their prior weight loss, with similar changes in cardiometabolic variables. If weight rebound is common after cessation of Wegovy and other GLP-1s, payers who cover these drugs may well need to plan for an enormous per-member expenditure for patients who stay on GLP-1s indefinitely

Other savings strategies like manufacturer discount programs, comparison shopping and using HSA or FSA funds could help certain eligible adults get GLP-1s for as little as $25 a month

This stable blood sugar environment is particularly beneficial for those managing conditions such as diabetes or prediabetes, as it helps to lower the risk of complications associated with these disorders, ultimately leading to a better quality of life

Further research is needed to establish optimal dosing, treatment duration, and patient selection criteria specifically for PCOS management

The custom code used is available from the corresponding author upon reasonable request

Previous negative experiences with injections may create anticipatory anxiety that amplifies discomfort