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doi: 10.1146/annurev-animal-021419-083626
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[43] The primary metabolic pathway for melatonin involves cytochrome P450 enzymes, particularly CYP1A2, which may be significantly impaired in patients with severe hepatic dysfunction
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[DOI] [PubMed] [Google Scholar] 131.Rubino D, Abrahamsson N, Davies M, et al
