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Table S2) clearly illustrates that the beneficial effects of GLP1/E are not merely an extension of the positive impact of GLP1-based therapies on as yet another models of obesity, but rather represent a genuine phenomenon, which sets the grounds for the therapeutic use of this novel family of unimolecular compounds with hormonal multi-agonist activity in the personalized management of PCOS

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However, testosterone therapy is not indicated for weight loss per se and must be prescribed according to established clinical guidelines in men with confirmed biochemical and clinical evidence of androgen deficiency [19,33]