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Normal synaptic activity can be disrupted by mitochondrial dysfunction, aberrant glutamate signaling, and toxic protein aggregates, resulting in synaptic hyperexcitability, loss of dendritic spines, and impaired plasticity

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In addition, GLP-1s slow gastric emptying, meaning food stays in your stomach longer

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SGLT2 inhibitors have proven efficacy in slowing chronic kidney disease progression, reducing albuminuria, and decreasing risk of end-stage renal disease