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10.1038/emm.2013.47 62 IqbalA
The relationship between dose and heart rate is clear enough that reducing the dose will reduce the cardiovascular effect proportionally

54 Adsorption transcytosis could be another mechanism involved in exendin-4 and lixisenatide crossing the BBB

Despite this lower bioavailability, clinical trials have shown that properly dosed oral GLP-1 medications can achieve similar effectiveness to injectable versions for both blood sugar control and weight loss
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