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Importantly, these studies demonstrate a consistent pattern: whilst retained gastric contents are significantly more common in GLP-1 RA users, the absolute rates vary considerably depending on patient factors, medication duration, and assessment methods [35]

Another potential mechanism by which central GLP-1R activation could stimulate hepatic FGF21 production is via the hypothalamic-pituitary-adrenal (HPA) axis

GLP-1s are approved for weight loss in adults who have a body mass index of 30 or higher, and those who are overweight with a body mass index of 27 or higher with at least one weight-related health condition such as high blood pressure, high cholesterol and type 2 diabetes
2), demonstrating durability of dosing

One of the most common side effects reported for all GLP-1R agonists is malaise (Kanoski et al., 2012)

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