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Details of the National Institutes of Health-funded study were published this week in a Nature paper titled A brain reward circuit inhibited by next-generation weight-loss drugs in mice. In it, the team reported that they investigated the small-molecule GLP-1s including Eli Lillys recently approved drug orforglipron, also known by the brand name Foundayo, as well as danuglipron, an oral GLP-1 that was being developed by Pfizer until the company decided to discontinue its development in 2025

These findings suggest that GLP-1R stimulation may exert differential effects depending on the neurobiological state associated with alcohol dependence [73]

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Assuming this pilot is successful, which I hope it is, we may later look at this moment as an inflection point when we moved from a reactive, sick-care model to a prevention-based model. Why have obesity rates risen so dramatically in the U.S

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[28] GDM increases the risk of complications like fetal macrosomia, preeclampsia, and type 2 diabetes postpartum
