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The American College of Physicians recommends using PPIs at the lowest effective dose for the shortest duration necessary

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Yet not one of them went through long-term trials to determine whether or not they would be safe for a lifetime

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People taking GLP-1 medications commonly report reduced food cravings, less emotional eating, and a quieting of the constant mental preoccupation with food that researchers call "food noise." Animal studies have also shown that GLP-1 receptor activation reduces the rewarding properties of high-calorie food in the brain findings confirmed in a landmark randomized, placebo-controlled neuroimaging study in humans ( van Bloemendaal et al., Diabetes, 2014 )