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If this apparent difference between GLP-1 agonists is mediated by characteristics of exendin-4, a species-specific effect, or due to the dosage remains to be elucidated, as the included studies have only been performed in mice and in a small range of concentrations (14, 15)

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Additional trials of GLP-1 for addiction will add confidence, but there is already far more evidence of GLP-1 efficacy for addiction than mRNA vaccines had for COVID when Operation Warp Speed was launched

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However, there are pathways to continue preparing tweaked versions of semaglutide under federal law "when a prescriber judges that [a] particular compounded formula is not available commercially and achieves a clinical difference for the patient," says the group's CEO, Scott Brunner