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Once-Weekly Semaglutide in Adults with Overweight or Obesity. New England Journal of Medicine , 384, 989-1002

doi: 10.1007/s12272-017-0976-0 [DOI] [PubMed] [Google Scholar] 225.Jamei M, Dickinson GL, Rostami-Hodjegan A

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Pharmacological: Natural GLP-1: Secreted 5-30 minutes after meals, returns to baseline within 2 hours Weekly injection: Sustained elevation for 168 hours with gradual decline Microdosing: Intermediate pattern with regular, smaller peaks The Case Against: Significant Drawbacks 1

Like most medications, GLP-1s have potential side effects