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Circulation, 115(7), 840845

At their current prices, GLP-1 drugs are not cost-effective for weight loss (see sidebar at right)

For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting

This is for public awareness only and is not my personal medical advice

A recent nationwide estimate of obesity indicated that 42% of adults aged 20 and over are obese

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