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A post hoc analysis from the LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) trial examined the effects of liraglutide vs placebo in subjects aged 75 years (n = 836) and in those aged 6074 years (n = 6183) [34]
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(2001) Regional differences in peptide degradation by rat cerebral microvessels: a novel regulatory mechanism for communication between blood and brain

The cohorts differed in demographics, comorbidities, and medications
