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FDA Approval & Safety Data: Wegovy (Semaglutide): FDA approved for cardiovascular risk reduction in adults with CVD and obesity (March 2024)

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Safety depends on: Personal medical history Thyroid cancer history Pancreatitis history GI sensitivity Cardiovascular risk profile Both carry boxed warnings regarding thyroid C-cell tumors observed in animal studies

Zimmer ER, Parent MJ, Souza DG, Leuzy A, Lecrux C, Kim HI, et al

Sustained Gs signaling mediated by vasopressin type 2 receptors is ligand dependent but endocytosis and -arrestin independent

Preservation of lean mass even in a moderate calorie deficit
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