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Patients should be advised to rise slowly from sitting or lying positions if experiencing dizziness, particularly during treatment initiation or dose escalation

[DOI] [PubMed] [Google Scholar] 33.Wilding JPH, et al

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In findings from a randomized controlled trial, youths with severe obesity who achieved a 5% or greater BMI reduction during the trials run-in phase and were randomly assigned to exenatide extended-release (Bydureon, AstraZeneca) had a smaller BMI increase after weight loss than those randomly assigned to placebo

Seek immediate medical attention for the following warning signs: Severe abdominal pain , particularly if persistent or radiating to the back, which may indicate pancreatitis (a rare but serious adverse effect) Persistent vomiting that prevents adequate fluid intake Signs of dehydration including decreased urination, dark urine, dizziness, dry mouth, or confusion Hypoglycemia symptoms such as shakiness, sweating, rapid heartbeat, hunger, confusion, or irritability (especially in patients taking insulin or sulfonylureas) Symptoms of gallbladder disease such as right upper abdominal pain, fever, or jaundice (yellowing of skin or eyes) Severe constipation or inability to pass stool or gas, accompanied by abdominal distention Signs of allergic reaction including rash, swelling of face/tongue/throat, or difficulty breathing (call 911) Patients with type 2 diabetes should monitor blood glucose levels more frequently during periods of significant nausea or vomiting, as reduced food intake can affect glycemic control

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