glp-1 for mash Incretin-based therapies in MASLD/MASH: from receptor agonists to dual and triple agonists Mechanistic interplay among THRβ agonist,

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The body weight reduction during treatment with SGLT2is has been considered modest, though it provides large cardiovascular benefits

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GLP-1s are forcing us to look at the body holistically, for sure and how signalling is affected in different people / conditions

Br J Pharmacol 165: 414423, 2012

Although mechanisms underlying the BP-lowering effects of SGLT2i are unclear, SGLT2i presumably acts primarily by decreasing circulating plasma volume through osmotic and natriuretic diuresis in the early stages of administration and later by suppressing sympathetic nerve activity in the long term [8, 9]