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PMID: 55 LinLXuXYuYYeHHeXChenSet al

Professor Ania Jastreboff, MD, PhD Yale University provided an overview #ADA2026 of the TRIUMPH-1 trial for Retatrutide, the investigational triple G medicine from Eli Lilly and Company The unique trial design provided insights beyond #weightloss #obesity and also encompassed relevant endpoints for co-morbidities such as knee osteoarthritis and obstructive sleep apnea, two comorbidities highly sensitive to weight loss

This pace reflects the combined effects of appetite suppression, increased meal satisfaction from smaller portions, and modest improvements in blood sugar regulation that support metabolic efficiency

It can also slow intestinal motility, which is the wave-like movement that pushes stool forward

A new generation of highly effective, hormone-based pharmacotherapeutics, including glucagon-based therapies for obesity, is on the horizon, which have both local and central (gut-brain axis) actions [5]

This dual actionreduced appetite plus delayed gastric emptyingcreates a powerful environment for calorie reduction without the constant hunger that often derails traditional diets