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In one study, nearly three-quarters of teens who received semaglutide experienced a weight loss of 5% or more compared with 18% of patients who experienced that degree of weight loss who received a placebo

Some patients who stop taking GLP-1s report that their cravings and the weight returns

What raises concerns are some of the recent reports of serious ADRs associated with GLP-1RAs: (i) Pfizers disclosure of elevated aminotransferases in users of lotiglipron (a novel oral GLP-1RA) is indicative of hepatocellular injury [11]

This injectable targets GLP-1 and GIP receptors for maximal efficacy, achieving up to a 20.9% body weight reduction in trials

Caroline M, Apovian L, Aronne, Sara RB

You still enjoy eating, but it doesn't drive behavior in the same way" [17]