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Genetic predispositions may influence initial tolerability, appetite suppression intensity, and optimal injection frequencythough individual response remains multifactorial and requires ongoing clinical observation
Rotate injection sites to prevent lipodystrophy (tissue changes from repeated injections in the same area)

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Our findings thus reveal the origin of the longevity signalling in response to germline ablation, underscoring the interaction of stem cells and their niche in metazoan ageing

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