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GLP-1 crosses the blood-brain barrier in limited amounts, but the brain also produces its own GLP-1 through neurons in the nucleus tractus solitarius (NTS) of the brainstem

Retatrutide might result in marginally quicker and more substantial weight loss

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It works by increasing insulin release from the pancreas when blood sugar is high, reducing the amount of glucose produced by the liver, and slowing gastric emptying

Journal of Clinical Endocrinology & Metabolism , 109(4), 12341246

Collectively, these data confirm that weekly subcutaneous retatrutide produces clinically meaningful, dose-dependent weight loss across a range of metabolic populations and study durations