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These drugs mimic the effects of the naturally occurring GLP-1 hormone, which is produced in the small intestine and plays a crucial role in regulating insulin secretion, glucose homeostasis, and appetite.

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Although these mechanisms have been exploited to facilitate weight loss, these medications have also been indicated for patients with cardiovascular or renal diseases, all of which have caused a recent drastic rise in prescribing GLP-1 RAs

Mechanistic hypotheses include reduced leptin-driven T-helper (Th)1/Th17 activity, improved adipokine balance, and modulation of gut-thyroid axis pathways

It helps maintain gut health, support metabolic performance, and promote immune and internal balance over time.

Summary GLP-1 RAs offer a multifaceted therapeutic strategy in PD, targeting both central neurodegenerative processes and peripheral metabolic dysfunction